Abstract
To the Editor: Modern immunoassays are notoriously prone to interferences from a variety of sources, including lipids, antibodies, fibrin strands, and other particulates (1). As more laboratories adopt plasma as their specimen of choice, interference from particulate matter becomes of greater significance. A variety of interferences have been associated with cell debris, microclots, and other particulate matter found in lithium heparin plasma separator tubes (2, 3). The presence of particulates is associated with improper use of plasma separator tubes, for example, not following manufacturer's recommended centrifugation protocol or remixing specimens after centrifugation (4). Our …
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