SP-selectin plasma levels in obesity: Association with insulin resistance and related metabolic and prothrombotic factors

Abstract

Background and aim Soluble P-selectin (sP-sel) represents a marker of platelet activation. This study was addressed to investigate the associations of sP-sel plasma levels with anthropometric parameters, insulin resistance, and related metabolic and prothrombotic factors. Methods and results 50 non-diabetic women, 17 with normal weight and 33 overweight and obese, aged 18–55 years, were examined. Measurements included body mass index (BMI), central fat accumulation (evaluated by waist circumference), systolic and diastolic blood pressure levels, fasting plasma concentrations of sP-sel, glucose, lipids (triglycerides, total cholesterol and HDL-cholesterol), insulin, and prothrombotic factors (plasminogen activator inhibitor-1, von Willebrand factor, fibrinogen), and insulin resistance (estimated by the homeostasis model assessment: HOMA IR). Overweight and obese women had higher fasting plasma sP-sel concentrations compared to normal-weight controls ( P < 0.05). sP-sel concentrations were positively correlated with BMI, HOMA IR, systolic and diastolic blood pressure, fasting insulin, triglyceride and PAI-1 plasma levels ( P < 0.05 for all the correlations). When a multiple regression analysis was performed, with P-sel as dependent variable and all the other parameters as independent variables, P-sel did not maintain a significant relationship with any of these variables. Conclusions s-P-selectin plasma concentrations are higher in overweight and obese insulin resistant subjects, thus possibly contributing to the cardiovascular risk of these patients. However, body fatness and insulin resistance are not independent determinants of fasting plasma sP-sel concentrations.