Abstract
Light and electron microscopic immunocytochemistry showed extensive increases in the number of calcitonin gene-related peptide immunoreactive (CGRP-IR) nerve fibers subjacent to injured root dentin of rat molars. Sprouting was greatest at 4 days and returned to normal 10–21 days post injury. Non-CGRP-IR fibers were also increased at 4 days. The result suggest that rapid reversible sprouting of sensory nerve fibers may be an integral part of tissue reactions to injury.
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