Abstract
The attachment under gravity to a glass surface and subsequent spreading of chick heart fibroblasts has been studied by phase contrast, reflection interference (RIM), scanning electron (SEM) and transmission electron microscopy (TEM). It has been shown that a cell can pass from the rounded state to a fully polarized locomotory state in as short a time as 5 min. The initial stable attachment of the cell to the substratum is brought about by small-diameter protrusions. Fully polarized cells already display areas of close apposition to the substratum with sub-membranous filamentous aggregations analogous to the ‘plaques’ described previously in locomoting fibroblasts.
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