Abstract
This study is aimed at using spray drying method to codisperse it with the commonly used drug carrier lactose in different solvents and then pass it through a spray dryer to obtain different samples. The results showed that the dissolution rate and solubility of the samples obtained by dispersion in hot water and 25% ethanol were significantly higher. The water of crystallization peaks of the raw material disappeared at 105-125°C and 130-150°C (DSC). The excipient lactose had a small upward exothermic peak at 177°C and a significant heat absorption peak at 209°C before untreated (XRD). α-Lactose peaks were observed at 12.5°, 19.1°, 19.6°, and 19.9° at 2θ in both samples, and β-lactose peaks were found at 10.5° at 2θ in sample A, but not in sample B (FTIR). The complex sharp peaks of lactose at 1100 cm-1 and quercetin at 1700-1000 cm-1 became moderated (SEM). The sample obtained by spray drying has a slit-type mesoporous structure with an average pore size of about 9.3 nm.
Highlights
Quercetin (3,5,7-trihydroxy-2-(3,4-dihydroxyphenyl)-4Hchromen-4-one) is an important flavonoid; it is a bright citrus yellow needle-like crystal, completely insoluble in cold water but its solubility can be increased by heating, very soluble in solvents such as alcohol and lipids
According to the XRD spectra (Figure 3), α-lactose peaks were observed at 12.5°, 19.1°, 19.6°, and 19.9° at 2θ in both samples, and β-lactose peaks were found at 10.5° at 2θ in sample A, but not in sample B
It was demonstrated that the solubility of quercetin increased after performing spray drying, and the solubilization effect was more pronounced for the sample obtained with 25% ethanol
Summary
Quercetin (3,5,7-trihydroxy-2-(3,4-dihydroxyphenyl)-4Hchromen-4-one) is an important flavonoid; it is a bright citrus yellow needle-like crystal, completely insoluble in cold water but its solubility can be increased by heating, very soluble in solvents such as alcohol and lipids It is one of the most common flavonoids in various foods and is found in a variety of fruits, vegetables, grains, and leaves, with green tea, apple, radish leaves, cranberries, apples, onions, buckwheat, and cilantro being among the more common types [1]. After ingestion into the body, quercetin metabolites appear in plasma 30 minutes after ingestion but are excreted in large quantities within 24 hours [7] This suggests that quercetin is rapidly cleared from the blood and has a short half-life. Numerous factors contribute to its practical application with significant difficulties and obstacles
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