Abstract
This study describes the preparation and characterization of hydroxyapatite-5-Fluorouracil (5FU) granules, which are intended to be used as chemotherapeutic delivery matrices and bone regeneration templates. Suspensions of hydroxyapatite (Hap) nanoparticles in 5FU solution are spray dried as micro sized granules having donut type shape. Several spray drying temperatures are studied 80 °C being the optimized condition for obtaining granules composed by Hap and 5FU without secondary phases. The produced granules at 80 °C reveal a fast releasing rate of 5FU when soaked in buffer phosphate solution maintained at physiological temperature (37 °C), thereby indicating the potential application of the produced Hap matrices for drug delivery systems (DDSs).
Highlights
The chemical similarity of hydroxyapatite [HAP, Ca10(PO4)6(OH)2] to the calcium phosphate phases in bone and its excellent biocompatibility make it an attractive biomaterial for medical applications
The tests were performed with three types of granules: unloaded granules (UG) used as controls and 5-FU loaded granules produced at spray drying temperatures of 80°C (LG80) and 120°C (LG120), respectively
Since different body tissues may react in very different ways towards external stimuli and drugs, we have chosen cells originating from two relevant body tissues
Summary
The chemical similarity of hydroxyapatite [HAP, Ca10(PO4)6(OH)2] to the calcium phosphate phases in bone and its excellent biocompatibility make it an attractive biomaterial for medical applications. To affect a certain cell type or to increase their effect, nanoparticles can be loaded with drugs. Spray drying is a fast and straightforward process that allows the production of granules [12, 13] loaded with drugs in a single step.
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