Spray Dried Buccal Mucoadhesive Microspheres based on Okra Mucilage: Formulation and In vitro Evaluation

Abstract

The goal of this work was to create and assess spray-dried buccal mucoadhesive microspheres containing darifenacin Hbr based on okra mucilage. Okra mucilage was used to create the microspheres in various ratios. Several parameters were used to characterize the buccal mucoadhesive microspheres: drug release studies in vitro, ex-vivo mucoadhesive test, swelling test, percentage yield, thermal analysis, scanning electron microscopy, X-ray diffraction, drug incorporation efficiency study, and stability study. In a modified Franz diffusion apparatus, the microspheres were tested for in vitro drug release in a 6.8 phosphate buffer solution for eight hours. The maximum release of 94.65% was displayed. Data was subjected to zero order, first order, Higuchi, and Korsemayers-Peppas models to ascertain the mechanism of release. The in vitro release study's findings indicated that a sustained release was seen. Studies on mucoadhesion have shown a clear relationship between okra mucilage concentration and mucoadhesion. Mucoadhesion and drug incorporation efficiency did not alter, according to the formulation stability analysis.