Abstract
Methods At a national referral centre, over 4 years, 87 consecutive recruited patients wtATTR amyloidosis underwent CMR. The diagnosis was confirmed by histological proof of amyloid (62%), exclusion of TTR mutations (100%) and characteristic features including bone tracer scanning (DPD grade 2-3 in 100%). CMR had precipitated the referrals in 71% of the cohort. Standard long and short axis cines derived the presence and distribution of LVH, relative wall thickness (RTW), inversion of the septal curvature and LV remodeling patterns were determined.
Highlights
WtATTR amyloidosis is an under-diagnosed and underappreciated cause of heart failure
To analyze the geometric pattern of cardiac hypertrophy in patients with wild-type transthyretin amyloidosis using cardiovascular magnetic resonance (CMR) and to analyze the diagnostic implications
Inversion of the septal curvature was found in 34% of patients, features typically associated with hypertrophic cardiomyopathy
Summary
Spotting senile systemic amyloidosis: why we miss it Marianna Fontana1*, Cristina C Quarta, Janet Gilbertson, Thirusha Lane, Carol J Whelan, Julian D Gillmore, Philip N Hawkins, James C Moon. From First European Congress on Hereditary ATTR amyloidosis Paris, France. 2-3 November 2015
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