Spotlight on the September 16 Issue

Abstract

Analysis of 418 twin pairs enabled improved understanding of the genetic architecture of epilepsy syndromes and emphasized the utility of the 2010 International League Against Epilepsy organizational system. Selected conventional molecular testing revealed relevant variants in 10% of cases. These data are critical for strategic planning for large-scale next-generation sequencing studies. See p. 1042 From editorialists Guerrini & Buchhalter: “As next-generation sequencing in large cohorts emerges, complexities in the genetic basis of epilepsy, as underlined by twin studies, should be kept in mind.” See p. 1038 The authors report a …