Abstract
Fifty-three participants recruited at 3½ months post HIV transmission were followed for 6 months, with 23 participants receiving antiretroviral therapy. In early HIV infection, cerebral metabolite markers of inflammation increased in antiretroviral therapy-naive participants and stabilized after initiation of antiretroviral therapy. Early antiretroviral therapy may limit CNS inflammation. See p. 1592 From editorialists Cysique & Koelsch: “…future investigations into the effects of early therapy on brain pathology would benefit from the inclusion of assessments of viral reservoirs (but innovative technology is needed to assess in vivo CNS reservoirs), as these results would constructively inform …
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