Abstract
#### Notable in Neurology This issue features an article that investigates whether common genetic variants in familial cerebral small vessel disease confer risk of lacunar ischemic stroke and deep intracerebral hemorrhage and another that associates the synaptic protein neurogranin with age-related cognitive decline in adults without dementia. A featured article examines the effect of caffeine on objective motor scores in Parkinson disease. ### Brain network connectivity differs in early-onset neurodegenerative dementia![Graphic][1] Connectomics may aid clinical diagnosis of early-onset Alzheimer disease and behavioral variant frontotemporal dementia. The authors investigated functional brain network architecture to provide insight into disease-specific variations that could aid differential diagnosis in … [1]: /embed/inline-graphic-1.gif
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