Abstract
This article shows that acute episodes of limb weakness mimicking periodic paralysis that dramatically respond to acetazolamide may be due to homoplasmic mitochondrial DNA MT-ATP6/8 mutations. It is important for diagnosis because of the maternal inheritance of these diseases. Further, the findings illustrate mitochondrial effect on plasma membrane ion transport. See p. 1810 From editorialists Ruff & Cannon: “…increasing inward rectifier potassium channel current may be the mechanism of action of acetazolamide-induced improvement of symptoms in hypokalemic periodic paralysis.” See p. 1806 The authors recruited 54 adult patients with mitochondrial …
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
