Abstract
By identifying the novel TLR3 mutations in 120 children with herpes simplex encephalitis (HSE), the authors determined the proportion of HSE patients (5%) with a mutation in TLR3 . HSE of childhood is not purely a virally determined illness but may result from genetic determinism of inborn errors of TLR3 impairing CNS intrinsic immunity to herpes simplex virus-1. See p. 1888 From editorialists Steiner & Tyler: “The observation that other genes associated with innate immunity were defective in some patients with HSE having normal TLR3… suggests that inborn innate immunity defects …
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