Spotlight on the March 6 Issue

Abstract

Statistical assessment established that age at onset of Huntington disease was determined by the length of the CAG expansion mutation, with no additional influence of the CAG repeat from the other chromosome. These findings indicate that discovery of therapeutics should be aimed at dominant effects of a single copy of the mutation. See p. 690; Editorial, p. 686 DaTSCAN imaging could be a helpful diagnostic tool in Parkinson disease. However, a comprehensive analysis of currently available evidence gives mathematically identical overall diagnostic accuracy …