Spotlight on the March 12 Issue

Abstract

Genetically testing a child at risk of Huntington disease (HD) can be challenging. The authors analyzed 76 patients with suspected juvenile HD, concluding that a family history of HD rather than the nature of presenting symptoms should primarily guide the decision. Nevertheless, a proportion of symptomatic children with positive family history will test negative. See p. 990 From editorialists Lehman & Nance: “The greatest challenge to the clinician is the 10- to 20-year-old patient presenting with behavioral symptoms or cognitive changes, as attentional difficulties, depression, and anxiety are common disorders in …