Abstract
The authors used H215O positron emission tomography to examine photophobia induced by continuous luminous stimulation covering the whole visual field in 8 migraineurs during spontaneous migraine attacks. Photophobia was found to be a consequence of visual cortex hyperexcitability enhanced during migraine attack by trigeminal activation and also by brainstem activation. See p. 213; Editorial, p. 206 Two independent cohorts were used to test and validate groups identifying the first robust genetic modifier of Duchenne muscular dystrophy (osteopontin). Future clinical trials should consider stratification for osteopontin modifier genotype, …
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