Abstract
#### Notable in Neurology This issue features an article that explores whether disease-modifying therapies exert differential effects on rates of retinal atrophy in relapsing-remitting multiple sclerosis and another that establishes sphingosine 1-phosphate lyase deficiency as a cause of Charcot-Marie-Tooth disease. A featured article investigates the uniformity of brain death determination guidelines through comparison of those at top-ranked neurologic institutions. ### Neuropathology of SUDEP: Role of inflammation, blood–brain barrier impairment, and hypoxia![Graphic][1]</img> Much is unknown about the mechanisms leading to sudden unexplained death in epilepsy (SUDEP), especially at the brain tissue level, hampering prevention efforts. The authors searched for evidence … [1]: /embed/inline-graphic-1.gif
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