Abstract
Resting-state fMRI at 3 T was performed in 16 cognitively unimpaired patients with Parkinson disease (PD) and in 16 controls. A disruption of the default-mode network was revealed in patients with PD, with absence of structural differences between patients and controls; altered default-mode network function may have a role in the development of cognitive decline in PD. See p. 2226 From editorialists Filippi & Kulisevsky: “The main unanswered question is whether the observed functional abnormalities are sensitive to the progression of PD cognitive deficits and have a role in the prediction of the risk of developing dementia.” See p. 2222 ![Graphic][1] Twenty-five individuals … [1]: /embed/inline-graphic-1.gif
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