Spot urine protein/creatinine ratio—A quick and accurate method for diagnosis of pre-eclampsia

Amita Sharma,Bhagoliwal Ajai,Pandey Kiran

doi:10.4236/ojog.2013.38109

Abstract

Objective(s):To assess the diagnostic accuracy of spot urine protein-creatinine (P/C) ratio and its compareson with 24-hour urine proteinuria for predicting eclampsia. Method(s): Spot urine P/C ratio was determined in a mid-stream urine sample, and the 24-hour urine protein was measured. The correlation between the spot P/C ratio and 24-hour urine protein amount was done. Logistic regression analysis and ROC curve analysis have been used to analyse data. Result(s): There was a strong correlation between the spot P/C ratio and 24-hour urine protein excretion (pearson’s correlation coefficient r = 0.71; P specificity of 69% and 75% respectively. Conclusion(s): Spot urine P/C ratio is a quick and reliable tool which can be used as an alternative method for evaluation of proteinuria for diagnosis of pre-eclampsia.

Highlights

IntroductionPre-eclampsia is a major cause of maternal and fetal morbidity and mortality in India
Pre-eclampsia is a multisystem disorder complicating 5% - 10% of pregnancy [1]
In this study a total of 126 pregnant women with preeclampsia were selected according to the inclusion and exclusion criteria.14 were excluded from the study, 7 were delivered before completion of 24 hour urine collection, 3 were diagnosed with chronic hypertension and 4 were having urinary tract infection

Summary

Introduction

Pre-eclampsia is a major cause of maternal and fetal morbidity and mortality in India. This is a pregnancy specific syndrome of reduced organ perfusion secondary to vasospasm and endothelial activation [2]. The minimum criteria for the diagnosis of pre-eclampsia are hypertension plus proteinuria. The gold standard for diagnosis of significant proteinuria is 24 hours urine collections [3]. The collection of urine for 24 hours is timeconsuming and needs strong co-operation; requires hospitalization, inconvenient, costly and inaccurate due to incomplete collection and poor compliance. This can delay diagnosis and management of pre-eclampsia

Methods

Results

Discussion

Conclusion