Abstract
Some of the changes in clinical signs and serum constituents which follow sporidesmin poisoning and experimental obstruction of the common bile duct in the sheep, were compared. Following either of these experimental procedures the sheep became iaundiced and showed loss of appetite and progressive wasting. The changes in serum constituents were also closely related as scrum bilirubin, cholesterol and glutamic-oxaloacetic transaminase (SGOT) were elevated and glutamic-pyruvic transaminase (SGPT) and alkaline phosphatase tests remained within or close to normal limits. However, there was a marked increase in gamma globulin and the zinc sulphate turbidity following sporidesmin poisoning, whereas the levels of these parameters were within or close to normal limits following experimental obstruction oj the common bile duct. These results were interpreted as further evidence of the obstructive basis of the jaundice which develops in sporidesmin poisoning, and natural facial eczema, and the differences between the 2 groups in the serum gamma globulin and zinc sulphate turbidity test were attributed to the inflammatory nature of the bile duct lesion in sporidesmin poisoning.
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