Abstract
Creutzfeldt–Jacob disease (CJD) is a rare neurodegenerative disease with a rapid progressive course. Clinically, general symptoms include progressive dementia, ataxia, myoclonus and akinetic mutism, in addition to other presentations such as alien hand. Here, we describe a patient with symptoms resembling corticobasal degeneration (CBD) who was diagnosed with CJD at follow up.
Highlights
Creutzfeldt–Jacob disease (CJD), a common spongiform encephalopathy, is a fatal neurodegenerative disease
Some neurodegenerative diseases presenting with rapidly progressive dementia such as Alzheimer’s disease, dementia with Lewy Bodies, frontotemporal dementia, meningoencephalitis, progressive supranuclear palsy, CADASIL, paraneoplastic encephalomyelitis, and corticobasal degeneration (CBD), can mimic CJD and make ia challenge in differential diagnosis [2]
The patient was diagnosed with CJD based on EEG findings, radiological findings, and cerebrospinal fluid (CSF) data
Summary
Creutzfeldt–Jacob disease (CJD), a common spongiform encephalopathy, is a fatal neurodegenerative disease. The patient was diagnosed with CJD based on EEG findings, radiological findings, and cerebrospinal fluid (CSF) data. A 69-year-old, right-hand dominant female consulted our clinic with symptoms of clumsiness noticed by her family, in addition to weakness of her left arm and visual disturbance She had presented to another outpatient clinic with symptoms of visual disturbance and dizziness 2 months earlier and all the clinical investigations were normal. Given the rapid progressive clinical course and asymmetrical nucleus caudatus and cortical diffusion restrictions, CSF was sent to two independent laboratories for detection of the 14-3-3 protein biomarker. The results of both laboratories were positive. The initial diagnosis. patient was transferred to another hospital by her family after
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