Spontaneously Self-Assembled Microgel Film as Co-Delivery System for Skincare Applications.

Garbine Aguirre,Pablo Taboada,Laurent Billon

doi:10.3390/pharmaceutics13091422

Abstract

Nowadays, the design of innovative delivery systems is driving new product developments in the field of skincare. In this regard, serving as potential candidates for on-demand drug delivery and fulfilling advanced mechanical and optical properties together with surface protection, spontaneously self-assembled microgel films can be proposed as ideal smart skincare systems. Currently, the high encapsulation of more than one drug simultaneously in a film is a very challenging task. Herein, different ratios (1:1, 3:1, 9:1) of different mixtures of hydrophilic/hydrophobic UVA/UVB-absorbers working together in synergy and used for skin protection were encapsulated efficiently into spontaneously self-assembled microgel films. In addition, in vitro release profiles show a controlled release of the different active molecules regulated by the pH and temperature of the medium. The analysis of the release mechanisms by the Peppas–Sahlin model indicated a superposition of diffusion-controlled and swelling-controlled releases. Finally, the distribution of active molecule mixtures into the film was studied by confocal Raman microscopy imaging corroborating the release profiles obtained.

Highlights

Even if the performance of the most effective products is boosted by the discovery of new active molecules, the design of new-targeted delivery systems is the backbone of the current research
Over the last few years, skincare applications, which require several simultaneous treatments, have directed their attention to advanced materials able to interact with the skin as smart delivery systems at the same time that they provided different advanced properties such as surface protection, mechanical and optical properties [1,2,3]
Particular attention is paid to the use of different biopolymers such as zein, chitosan, collagen, hyaluronic acid, gelatin and elastin, among others as a material matrix for scaffolds design [4,5,6]

Summary

Introduction

The efforts of the beauty and personal care industries to meet youthful, vibrant, and healthy skin criteria can be addressed through the smart delivery of skincare products. In this sense, even if the performance of the most effective products is boosted by the discovery of new active molecules, the design of new-targeted delivery systems is the backbone of the current research. In the case of patients suffering from extreme skin injuries, recent advances are focused on the use of tissue engineering for the regeneration of damaged tissues In this regard, particular attention is paid to the use of different biopolymers such as zein, chitosan, collagen, hyaluronic acid, gelatin and elastin, among others as a material matrix for scaffolds design [4,5,6]

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