Abstract
Intracerebellar nuclei in cerebellar explants derived from newborn mice were recognized as focal points of converging Purkinje cell axons. Morphological studies demonstrated characteristic architectonic features and abundant typical large and small intracerebellar nucleus neurons. Spontaneous electrical activity was recorded extracellularly from cortical regions of cerebellar cultures, but no endogenous activity was evident in recording from intracerebellar nuclei. These neurons were pharmacologically isolated from the inhibitory influence of Purkinje cells by application of bicuculline and lidocaine-HCl, without the resultant emergence of endogenous activity. Intracerebellar nucleus neurons in deafferented cerebellar cultures proved incapable of generating spontaneous electrical discharge, suggesting that background excitatory activity in intracerebellar nuclei in situ may be driven by collaterals of cerebellar afferent fibers.
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