Abstract

The incidence of spontaneous mineralization in the brain of aged B6C3F1 mice and its histopathological and ultrastructural features were studied. Mineralized foci were observed in the wall of small blood vessels of the thalamus. They varied in shape and size and were positive for von Kossa stain. Ultrastructurally, electron dense deposit were shown in the thickened basement membrane. The lesions were detected first at 58 weeks of age and the incidence and the severity were higher in aged animals.

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