Spontaneous Tumor Lysis Syndrome in a Patient with Neuroendocrine Lung Carcinoma

Abstract

Tumor lysis syndrome is one of the most important oncological emergencies and may develop after chemotherapy or sometimes spontaneously. Various biochemical abnormalities may occur in the body due to excessive tumor cell destruction in tumor lysis syndrome. In this case report, we aimed to describe a male patient who developed tumor lysis syndrome due to high tumor burden. Laboratory testing on admission revealed acute renal failure, high anion gap metabolic acidosis, hyperuricemia, hyperkalemia, hyperphosphatemia, and hypocalcemia. The patient was diagnosed with spontaneous tumor lysis syndrome as a result of clinical and laboratory evaluations and he was hospitalized. This case report aimed to explain that tumor lysis syndrome may rarely develop spontaneously in solid organ tumors with high tumor burden.