Spontaneous Splenic Rupture in Acute Myeloid Leukemia with Mixed-Lineage Leukemia Gene Rearrangement

Abstract

Spontaneous splenic rupture is a rare and potentially devastating entity associated with a wide variety of causes including, but not limited to, infections, inflammation, and neoplastic and iatrogenic causes. The clinical presentation of spontaneous splenic rupture is typically acute onset abdominal pain which is non-specific and may be confused with other causes of abdominal pain; failure to recognize this rare entity can result in sever morbidity and mortality. Here we present a 26 year-old obese female with a history of childhood immune thrombocytopenia (ITP), presenting for medical care with flulike symptoms.