Abstract
Abstract During recent studies on immunologically induced renal tubular disease (1), we noted a high incidence of spontaneous deposits of IgG and complement (C3) in glomeruli of untreated guinea pigs (2–4). We now describe the immunohistochemical, morphologic and functional status of kidneys of untreated guinea pigs of various ages. Materials and Methods. Twelve female guinea pigs of the Albany strain3 were studied in each of the following age groups: near-term fetus, 3 weeks, 3, 6, 12, 18 and 24 months. Six female guinea pigs, 16 months of age, were surveyed from each of the following closed colonies:4 Rockefeller, Dunkin, Camm and Fort Detrick Hartleys, and English Short Hairs. Three strain 2 and six strain 13 female guinea pigs,5 one year of age, were studied. Three 24-hr quantitative urinary protein determinations (5) were made on all animals 6 months of age or older.
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