Abstract
Naive adult male Wistar rats free to choose between water or 10% ethanol (v/v) spontaneously became water-preferring (WP) rats, as they drank mainly water (approximately 35 ml per day), or alcohol-drinking (ED) rats, as they also drank a significant amount of ethanol (approximately 14 ml per day). The selective CCK A receptor antagonist L-364,718 at doses selective for the CCK A receptor (5 μg/kg, IP) halved the consumption of alcohol of the ED rats without modifying their total liquid in take. In contrast, the CCK B antagonists L-365,260 or GV150013 were without effect when used at doses selective for the CCK B receptor. These data indicate that the CCK system could be involved in the modulation of alcohol intake. In particular, they suggest that CCK A receptors could play a role in the ethanol preference.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
