Abstract
Objective:Audio files of spontaneous signal streams generated byex vivoneuronal networks cultured on multi-electrode arrays generated an oscillating sine wave with an inherent musical quality. This was not anticipated considering that synaptic signals are “all - or – none”, and therefore digital, events.Methods:These findings may provide insight into why music can be perceived as pleasurable and invoke a calm mood despite that music is ultimately perceived and stored as a series of digital signals; it is speculated that music may reinforce and/or enhance this spontaneous digital stream.Results and Conclusion:These findings also support the relationship between music and mathematics.
Highlights
Music is often referred to as a universal language [1]
We examined synaptic signal streams generated by neuronal networks established on multi-electrode arrays (MEAs) that interfaced with computer software
Audio files of spontaneous signal streams generated by a voltage-controlled oscillator (VCO) generated an oscillating sine wave with an inherent musical quality (Supplemental files 1 and 2)
Summary
Music is often referred to as a universal language [1]. While distinct differences are observed among cultures, music is prevalent in all cultures [2], which may derive from the ability of some forms of music to provoke an emotional response and to instill a calming mood [3, 4]. The sound is initially perceived as sonic vibrations that induce vibration of eardrum, which is sequentially transmitted to auditory neurons. Information regarding pitch and volume is delivered by differential stimulation of auditory sensory neurons. Continued transmission to the central nervous system is via all - or - none synaptic signaling. All sound, including music, is perceived and stored in memory, as a series of digital signals. Pleasing sensations arising from hearing music are of necessity derived from a corresponding sequence of synaptic pulses that has been stripped of the original analog nature. It remains unclear as to how the digital translation of music can retain what is perceived as pleasurable. We examined synaptic signal streams generated by neuronal networks established on multi-electrode arrays (MEAs) that interfaced with computer software
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