Abstract
A fluorescent nucleoside analogue, <TEX>$^AC$</TEX>, featuring two non-complementary nucleobases linked through an ethynyl group, was synthesized. The extended <TEX>${\pi}$</TEX>-conjugation imparts <TEX>$^AC$</TEX> with red-shifted absorbance (relative to adenine and cytosine) and pale-blue fluorescence. It spontaneously forms nanoparticles, which exhibit considerably enhanced fluorescence, without the help of any additional stabilizing agent. The DMSO/water ratio was an important factor influencing the construction of the NPs. X-ray crystallography confirmed the structure of <TEX>$^AC$</TEX>; dynamic light scattering and scanning electron microscopy confirmed the existence of the nanoparticles.
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