Abstract
THE discovery of thymus-derived (T) and bone marrow-derived (B) specific cell-surface markers in normal lymphocyte populations led to extensive studies of the cell lineage and differentiation pathways of various human and murine lymphoid neoplasms. Most spontaneous lymphomas and lymphocytic leukaemias in mice are members of the T-lymphocyte lineage1. Although B-lymphocyte tumours have been reported in mice, these neoplasms were induced experimentally, using carcinogens or Abelson virus2–5. We report here the characteristics of a spontaneous B-cell leukaemia derived from, and passaged in BALB/mice. This tumour seems to be analogous to human chronic lymphocyte leukaemia (CLL), and may provide a useful model for the study of this disease.
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