Spontaneous massive hemoperitoneum from hemorrhagic corpus luteum cyst as initial presentation of aplastic anemia

Abstract

Abstract While hemorrhagic ovarian cysts are quite common, rupture leading to spontaneous severe hemoperitoneum is much more rare, and in the setting of an acquired bone marrow failure syndrome, it can be a life-threatening event. We describe a 17-year-old female presenting with syncope, abdominal pain, and large-volume hemoperitoneum, associated with diffuse petechiae and oral purpura, who was found to have a hemorrhagic corpus luteum cyst at laparoscopic exploration. After discharge, the patient re-presented with severe anemia and thrombocytopenia, and was diagnosed with acquired severe aplastic anemia of unknown etiology.