Abstract
HIV A small number of HIV-infected individuals (<1%) can spontaneously control HIV in the absence of antiretroviral therapy. Because CD4+ and CD8+ T cell responses are thought to contribute to protection, HIV-responsive T cell receptors (TCRs) from these individuals are of considerable interest. Galperin et al. examined how three class II–restricted TCRs observed in spontaneous controllers are capable of binding a Gag peptide in the context of multiple HLA-DR molecules (HLA, human leukocyte antigen). The authors solved the structures of several TCR–peptide–HLA-DR complexes. The findings suggest that the ability of these TCRs to recognize the Gag peptide in the context of multiple HLA-DR allomorphs is shaped by extensive contacts between the TCRs and the peptide itself. Sci. Immunol. 3 , eaat0687 (2018).
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
