Abstract
A new colloidal carrier system, nanocapsules, using 2,3-diacyl- O- β-cyclodextrins is described. The nanocapsules were prepared by adding a mixture of an organic solution of 2,3-diacyl- O- β-cyclodextrins (with or without a lipophilic surfactant) and an oily phase to an aqueous solution (with or without a hydrophilic surfactant) whilst stirring. Nanocapsules with a mean size of 200 nm are formed progressively. Direct microscopic observation of the particles was carried out using transmission electron microscopy (TEM) combined with the freeze-fracture method. The influence of different constituents on the preparation process was studied: type of 2,3-diacyl- O- β-cyclodextrins (β-CD-C 6, β-CD-C 12 and β-CD-C 14), nature of the oily phase (benzyl benzoate, Miglyol 812®), and the surfactants used (Pluronic PEF68®, Span 85®). An investigation of lipophilic drug encapsulation was also carried out. The results of this study suggest that nanocapsules of 2,3-diacyl- O- β-cyclodextrins could be considered as a potential colloidal drug carrier system.
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