Spontaneous Flow Waves Detected by Laser Doppler in Human Skin

Abstract

The contribution of spontaneous variations in sympathetic nervous activity and perfusion pressure to the laser Doppler flux signal in human skin was studied in nine healthy subjects. Simultaneous recordings were made of laser Doppler flux, mean blood pressure, and blood flow in the radial artery. In the skin of the palm and sole, there was a significant and strong correlation between fluctuations in flux and radial artery velocity, which indicated a high degree of neural control of microcirculatory blood flow. This correlation decreased progressively toward the trunk and face. In the skin of the nose and at scattered sites on the face, trunk, and extremities, there was correlation between flux and mean blood pressure that indicated a predominantly "passive" vascular bed. At other sites, multivariate regression analysis revealed contributions of both blood pressure and sympathetic activity. In skin on the ear and forehead, a characteristic pattern of regular oscillations in flux, uncorrelated with blood pressure and sympathetic activity, was demonstrated. The laser Doppler signal from different skin sites thus contains varying contributions from variations in perfusion pressure, sympathetic nervous activity, and local, myogenic arteriolar vasomotion.