Abstract
In an investigation of the spontaneous efflux of beta-thromboglobulin (β-TG), 14C-norepinephrine (14C-NE) and growth stimulating activity (GSA), measured as incorporation of 3H-thymidine in rabbit aortic smooth cells, from platelets resuspended in Ca ++- and Mg ++- free buffer a continuous increase in 3H-thymidine incorporation was seen during 120 min. There was good stoichiometric parallelism between β-TG and 14C-NE during the 80 minutes the experiment lasted, indicating that norepinephrine is incorporated in α-granules and released by exocytosis.
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