Abstract
C57BL/6 mice are widely used for metabolic, cancer, and immunologic studies. High-caloric diets induce a heterogeneous phenotype in C57BL/6 mice, with the majority developing obesity and metabolic syndrome, while others remain lean and metabolically healthy.1 Western diets (WDs), methionine-deficient or choline deficient–based diets are used to study nonalcoholic fatty liver disease and nonalcoholic steatohepatitis (NASH), important risk factors for hepatocellular carcinoma development.2–4
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