Spontaneous cerebellar activity and its role in neurotoxicity

Abstract

Introduction. In performed experiments, the parietal electrocortical activity of the cerebral cortex and the activity of the cerebellar cortex were simultaneously recorded. The main purpose was to compare their spontaneous activity, as the recording was conducted during anesthesia. Material and Methods. We used 2-3 months old rats weighing 200 - 350 g. Two groups of rats with same characteristics were made. The first group of 15 rats (control group) was recorded under anesthesia and there was a change in spectral power in accordance with frequency ranges. The second group of 30 rats was recorded under the same experimental conditions, but the rats were treated intraperitoneally by aluminium chloride hexahydrate solution or with 1.5% solution of aluminium chloride hexahydrate per os. Discussion. Changes in spontaneous activity of the cerebellum during aluminium intoxication were compared with control values. It was shown that lesion and neurotoxicity during stable anesthesia led to desynchronization of the cerebellar activity. This is described by the change in fractal dimension of cerebellar electrocortical activity. The assumption is that the inhibition caused by anesthetic is compensated during aluminium intoxication. Conclusion. The cerebellum plays a role in compensation through changes in spontaneous activity. This response involves an increase in the value of fractal dimension of cerebellar electrocortical activity which is reduced in neurotoxicity.