Abstract
Background: To explore expression and immune infiltration of SPARC/osteonectin, cwcv, and maze-like domains proteoglycan 1 (SPOCK1) in Head and Neck squamous cell carcinoma. Methods: A total of 107 HNSC patients’ tissues and 15 adjacent normal tissues were collected in this study. Co-expressed gene and gene set enrichment analysis was detected using STRING and Linked Omics. Immune cell infiltration related to SPOCK1 was analyzed via TIMER. Results: The positive rate of SPOCK1 in HNSC tissues were significantly higher than that in normal tissues by immunohistochemical staining (p< 0.01). The expression of SPOCK1 in HNSC was a positive correlation with the level of immune infiltrating cells. In addition, we discovered that SPOCK1 was major involved in inflammatory response pathways, cancer cell proliferation regulation, cell cycle regulation, apoptosis, adhesion, cell-matrix interaction, etc. Conclusions: SPOCK1 plays a role in promoting cancer in HNSC, which was closely related to the malignant evolution of HNSC, and it was expected to become a prognostic molecular marker for HNSC patients and a potential target for immunotherapy.
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