Splice variants of the receptor for advanced glycosylation end products (RAGE) in human brain

Abstract

Previous studies indicate that the receptor for advanced glycosylation end products (RAGE) plays an important role in multiple pathological processes, including Alzheimer's disease. Currently there are three established isoforms of the RAGE receptor, with each isoform generated as the result of alternative splicing. It is presently unclear which of the RAGE isoforms are normally expressed in the human brain, nor has it been determined if additional RAGE isoforms exist in the human brain. In the present study we demonstrate for the first time that each of the three established RAGE isoforms, as well as three previously unidentified RAGE splicing variants, are normally expressed in the human brain. These data suggest that RAGE may have multiple functions in the human brain, mediated by the individual or coordinated efforts of the different RAGE isoforms, with alternative splicing generating individual RAGE isoforms that specifically interact with the various ligands present in the brain.