Splenomegaly and an abnormal peripheral smear associated with the use of danazol: Case report

Abstract

41 patients worldwide, as long as 10 years after operation.’ The nature of this protection is not completely understood. Although the QT, may be shortened after left stellectomy, this has not occurred in most cases. Laboratory and clinical evidence, however, shows an increased ventricular fibrillation threshold after left stellectomy or left stellate ganglion blockade.’ Drug therapy may be required after sympathectom) if ventricular arrhythmias persist. Use of &blockers in pregnancy, howe&, is controversial. Propranolol easily crosses the placenta and is also secreted into breast milk. Although use of propranolol during pregnancy has not been associated with congenital abnormalities, intrauterine growth retardation, neonatal hvpoglvceI I mia, fetal and neonatal bradycardia. respiratory depression. and meconium ileus of the neonate have been reported. Propranolol therapy during pregnancy should be limited to life-threatening conditions, in the lowest effective dosage, and for the shortest effective time. In patients at risk for cardiac arrhythmias, continuous maternal electrocardiographic monitoring during labor is critical. The patient should be placed on her side to minimize changes in pulse pressure during uterine contractions. Systemic analgesia and segmental epidural anesthesia should be used as necessary to provide comfort to the patient during labor and delivery. The second stage of labor may be shortened by the use of vacuum extractor or outlet forceps without increased risk to mother or infant.