Abstract
We examined splenectomy effect on subsequent administration of intensive, intermittent combination chemotherapy in patients with disseminated Hodgkin's disease. Otherwise comparable patients with Hodgkin's disease received more chemotherapeutic agents in a shorter period of time when they had undergone prior splenectomy. Asplenic patients had higher circulating platelet and lymphocyte counts prior to chemotherapy onset, most likely due to removing a splenic pool of these cells. After four courses of chemotherapy there was a proportionately greater fall in the white blood cell and platelet counts in the asplenic group. This indicates that asplenic patients tolerated delivery of greater amounts of drug in shorter periods of time, and this is reflected in their greater degree of myelosuppression. Preliminary data suggest that there may be enhanced response rate in the asplenic group.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
