Abstract
SummaryC57BL, C3H, C57BL/6, and DBA/2 parental marrow cells were injected at varying doses into lethally irradiated BC3F1 and B6D2F1 mice. Spleen weight in recipients was compared to spleen colony formation and Fe59 uptake. Results showed that increased spleen weight was proportional to formation of increased numbers of splenic nodules and percentage of Fe59 uptake. Data suggest that spleen weight, spleen colony formation, and Fe59 uptake are equally suitable assays, within appropriate limits, for studies on proliferation of marrow cell transplants in irradiated mice. Spleen weight is a useful index of growth for doses of transplanted marrow cells which promote recovery of hematopoietic injury in lethally irradiated mice.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callMore From: Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.)
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
