Abstract
Chinese onion (Allium chinense) is widely cultivated as a vegetable, native to China and cultivated in many other countries. Its bulbs are commonly processed into pickles and spices. In this study, seven new spirostanol saponins (5, 7, 9–11, 13 and 15) together with ten known congeners (1–4, 6, 8, 12, 14, 16 and 17) were isolated from the bulbs of Chinese onion and their structures were elucidated by spectroscopic analysis and chemical degradation. The isolated components were evaluated for anti-inflammatory and anti-proliferative activities. As a result, compounds 4 and 8 showed potent inhibitory effects on the lipopolysaccharides (LPS) induced nitric oxide (NO) production in murine macrophage RAW264.7. Compound 13 displayed potential inhibitory activity against five human cancer cell lines with IC50 values of 1.43–6.81 µM. Compound 14 exhibited significant selective inhibition against these cancer cells (IC50 2.22–15.58 µM), in comparison with the normal cells MRC-5 (IC50 > 100 µM).
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.