Abstract
It is well known that spirostane-type saponins show various bioactivities. In our on-going program of screening these kinds of constituents from natural products, Yucca schidigera was found to be rich in them, and nine new spirostanol saponins, Yucca spirostanosides A1 (1), A2 (2), B1 (3), B2 (4), B3 (5), C1 (6), C2 (7), C3 (8), and D1 (9), together with five known ones (10–14) were isolated from the plant. Their structures were elucidated by extensive spectroscopic methods, including 1D and 2D NMR and MS spectra, and comparing with published data.
Highlights
IntroductionAs one of the secondary metabolites, spirostanol saponins have been found to have broad bioactivities, such as antiproliferative, anti-inflammatory [1,2,3,4], anti-HIV [5], anti-bacterial [6], anti-fungi [7], and anti-hyperuricemic [8] activities, which make the phytochemical or bioactive researches for spirostanol saponins meaningful
The 70% EtOH extract of Y. schidigera stems were subjected to D101 column chromatography
(CC) (H2O → 95% EtOH), and 95% EtOH eluate was yielded, which was separated by Silica gel
Summary
As one of the secondary metabolites, spirostanol saponins have been found to have broad bioactivities, such as antiproliferative, anti-inflammatory [1,2,3,4], anti-HIV [5], anti-bacterial [6], anti-fungi [7], and anti-hyperuricemic [8] activities, which make the phytochemical or bioactive researches for spirostanol saponins meaningful. In our on-going program of investigating spirostanol saponins [3,4,8] from natural products, we found that Yucca schidigera Roezl (Agavaceae family) is a plant rich in these kinds of constituents. As one of the major industrial sources of steroid saponins, Y. schidigera is native to the desert of the southwestern United States and northern Baja California, Mexico [9]. The isolation of spirostanol saponins from Y. schidigera stems was studied, which led to the separation of nine new spirostane-type saponins, Yucca spirostanosides A1 (1), A2 (2), B1 (3), B2 (4), B3 (5), C1 (6), C2 (7), C3 (8), and D1 (9), along with five known ones, schidigera-saponins. A3 (10) and A1 (11) [9], 5β-spirost-25(27)-en-3β-ol-12-one 3-O-{β-D-glucopyranosyl-(1→2)-O[β-D-glucopyranosyl-(1→3)]-β-D-glucopyranoside} (12) [11], schidigera-saponins C2 (13) and C1.
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