Abstract
Three new spirobisnaphthalenes (1–3) were isolated from the mangrove-derived fungus Rhytidhysteron sp., together with five known derivatives (4–8). The structures of the compounds were established on the basis of extensive spectroscopic data, and the relative configurations of their stereogenic carbons were determined by a single-crystal X-ray crystallographic analysis. Compounds 3–5 displayed cytotoxicity against both cancer cell lines, MCF-7 and CaSki, while 2 was active only on CaSKi cells.
Highlights
Spirobisnaphthalenes, a series of compounds consisting of two naphthalene-derived C10 units bridged through a spiroketal linkage, have been mainly isolated from fungi [1,2,3,4,5]
In our continued investigation into new bioactive compounds from Thai mangrove-derived fungi, we describe the isolation and structure elucidation of three new spirobisnaphthalenes, rhytidones A–C (1‒3), together with five known derivatives from an endophytic
The Rhytidhysteron sp. fungus was cultured in malt extract broth (MEB) under static conditions for
Summary
Spirobisnaphthalenes, a series of compounds consisting of two naphthalene-derived C10 units bridged through a spiroketal linkage, have been mainly isolated from fungi [1,2,3,4,5]. This class of compounds is of great interest as potential leads for medicinal chemistry, since they have interesting structures and a variety of biological activities such as antibacterial, antifungal, anticancer, and antileishmanial activities [4,5,6,7]. All isolated compounds were evaluated for their cytotoxic activities against human cancer cell lines
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