Abstract
Three new spirobisnaphthalenes (1–3), a new, natural spirobisnaphthalene product (4), and two new 12-membered ring lactones (11–12), with six known compounds (5–10), were isolated from the seeds of Strychnos angustiflora. Their structures were elucidated by extensive spectroscopic analysis. The absolute configurations of 1–4 were assigned by computational methods. Compounds 1, 5 and 9 inhibited lipopolysaccharide-induced NO production in BV2 cells with IC50 values of 4.85, 2.05, and 1.16μM, respectively (positive control curcumin, IC50=1.42μM). This is the first report on the anti-inflammatory activities of spirobisnaphthalenes.
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