Spiral wave meandering in models of ventricular tissue as an antiarrhythmic target

Abstract

We characterise the effects of ionic conductance and concentration changes on the meandering patterns and dynamics of re-entrant excitation in models of mammalian ventricular tissue. An increase in the spatial extent of spiral wave meander might lead to an increased likelihood of self-termination of the re-entrant excitation, since the probability of the spiral core meeting and annihilating at the in-excitable tissue boundaries is increased. Thus, the spiral-wave meandering behaviour and dynamics provides a potential target for antiarrhythmic drugs.