Abstract
Patients with amyotrophic lateral sclerosis have limited treatment options and a 20% survival rate within five years of diagnosis. Small animal models show promise for halting the associated neurodegeneration when cellular therapeutics are delivered to the ventral horn of the spinal cord. A template-based guidance system was developed to facilitate percutaneous injections under MRI guidance to improve upon existing invasive and time-consuming surgical techniques. Procedure duration was 30[Formula: see text]min plus 5[Formula: see text]min per insertion, with a mean error of [Formula: see text][Formula: see text]2[Formula: see text]mm.
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