Abstract
Neurotrophic factors promote the formation of spines and synapses in neuron development and maintenance. Synaptic connections enhance memory in the brain. In this study, the effects of Kappaphycus alvarezii ethanolic extract (EKA) and its isolated cholesterol (iCHOL) on spinogenesis and synaptogenesis of hippocampal neurons were evaluated. Compared with the vehicle, both EKA and iCHOL significantly promoted generation of dendritic filopodia (2.4- and 2.2-fold, respectively) and spine (1.7- and 1.4-fold) formations in spinogenesis; they also increased presynaptic (3.6- and 2.6-fold), postsynaptic (2.5- and 2.9-fold), and cocolonized (3.8- and 3.0-fold) puncta, which enhances synaptic function (P< 0.05). Further, EKA- and iCHOL-treated neurons showed significantly improved functional presynaptic plasticity (1.6- and 1.4-fold, respectively, at 17 days in vitro; P<0.05). These results indicate that K. alverezii facilitates neuronal development, and support its use as a functional food to reduce neurological disorders and prevent brain aging via helping to reconstruct partially damaged neural networks.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
